Hydrophobic end-gated silica nanotubes for intracellular glutathione-stimulated drug delivery in drug-resistant cancer cells.
نویسندگان
چکیده
Intracellular glutathione-triggered doxorubicin release from silica nanotubes with hydrophobic labile cap was demonstrated for the drug-resistant cancer cell treatment.
منابع مشابه
Application of mesoporous silica nanoparticles for drug delivery to cancer cells
Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvanta...
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 31 شماره
صفحات -
تاریخ انتشار 2013